Huron-Perth OPP Community Street Crimes Unit were conducting a drug trafficking investigation.
They along with the Oxford-Brant Community Street Crimes Unit and the West Region Emergency Response Team executed a search warrant at a home on 12th Street Friday night.
Once inside, officers seized a quantity of methamphetamine, fentanyl, and cocaine with an estimated value of $4,876.
They also found cell phones, digital scales, drug trafficking materials, and cash.
Two men from Central Huron, 31 and 52 years of age respectively, a 44-year-old man from Huron East, and two women, a 29-year-old from South Huron and a 37-year-old from North Huron were arrested and later released.
All five will appear in a Goderich court on March 28th.