South Bruce OPP along with South Bruce Fire and Bruce County paramedics went to the scene on Highway 9 Sunday afternoon around 5:03 PM.
They arrived to find a motorcycle, SUV, and pick-up truck involved in a collision.
The motorcyclist was taken to hospital and pronounced dead.
Investigators are withholding the identity of the victim until next-of-kin have been notified.
A section of Highway 9 is closed as South Bruce OPP along with the Traffic Incident Management and Enforcement Team are determining what caused the crash.
They are asking witnesses to the crash to contact South Bruce OPP or Crime Stoppers.