The latest occurred between 8 AM and 11 PM last Friday at a property on Bruce Road 6 in Carrick Township.
Investigators are looking for a white Dodge Ram 3500 Diesel (license plate 722 1FH) with dually rear tires valued at $20,000.
The serial number is on file with police.
Two other stolen pick-up trucks are being investigated, one occurred on the same day as this theft.
Anyone with information on this theft is asked to contact South Bruce OPP or Crime Stoppers.