Officers were called to the scene at approximately 7:15 am at Concession Road 10 & Bruce Road 4 in South Bruce.
Police, Bruce County Paramedics and South Bruce fire attended the scene and transported the driver of a motorcycle to a local hospital where they were pronounced deceased.
The deceased has been identified as 47 year old Wayne Fischer of Bluevale.
The South Bruce OPP say they are continuing to investigate with assistance of the West Region Traffic Incident Management and Enforcement team.
Anyone with information on the incident is asked to contact the OPP or anonymously to Crime Stoppers.