South Bruce OPP along with Elmwood Fire and Grey County Paramedics went to an area on Bruce Road 19 Sunday night around 10:30.
First responders arrived to find an occupant in each vehicle without vital signs.
Both were pronounced dead at the scene.
West Region Traffic Incident Management and Enforcement Team were brought in to assist in the investigation.
They are asking any witnesses to contact OPP or Crime Stoppers.