One person is in a London hospital with serious but non-life threatening injuries.
South Bruce OPP were called to a single motor vehicle crash on Concession 2 between Bruce Road 4 and Side Road 5A in Culross Township.
A pick up truck was discovered Monday night around 8:40 in a ditch.
Investigators determined that the vehicle left the roadway and struck a tree before then.
OPP say the investigation is in its early stages.
Concession 2 was closed for several hours but has since reopened to traffic.